The peak lift of 12.1mm intake and 11.9mm exhaust will require upgraded valve springs and a titanium retainer with special attention to seal to retainer clearance. With the lift of this profile it is suggested to only use the 5041/5040 Titanium retainer and spring kits due to valve seal to retainer clearance. The 5041 can be used to 40+psi and the 5040 to 32psi on the R2 profile at 8500rpms without float or flutter issues.
The profile will work fine on the OEM Rocker Arm and the Zero-tick lifter or with the OEM lifter. They have seen gains of 25-30whp over the S2 profile on the stroked applications with much more possible when used with a ported head and aftermarket intake manifold.